Pooled analysis of petroleum case control studies

Chief Investigators

Dr AR Schnatter, ExxonMobil Biomedical Sciences, Inc., Canada
Dr Lesley Rushton, Imperial College, London

Funded by: CONCAWE(Conservation of Clean Air and Water in Europe)

This project is investigating the risk of leukemia from exposure to benzene in the petroleum industry. The aims of the study are to estimate the exposure-response relationship for benzene and leukemia and its subtypes and to investigate the induction period from first exposure to leukaemia diagnosis or death. Cases of leukemia and selected controls drawn from three similar petroleum industry cohorts based in Canada, the United Kingdom and Australia will be pooled. The exposure to benzene from specific jobs, operations and activities is individually estimated for the cases and controls. The risk associated with different levels of exposure can then be calculated.